Collen Masimirembwa Selected Research

Cytochrome P-450 CYP2B6 (CYP2B6)

1/2021	CYP2B6 Functional Variability in Drug Metabolism and Exposure Across Populations-Implication for Drug Safety, Dosing, and Individualized Therapy.
3/2015	CYP2B66, CYP2B618, Body weight and sex are predictors of efavirenz pharmacokinetics and treatment response: population pharmacokinetic modeling in an HIV/AIDS and TB cohort in Zimbabwe.
9/2013	Genetic variants of drug metabolizing enzymes and drug transporter (ABCB1) as possible biomarkers for adverse drug reactions in an HIV/AIDS cohort in Zimbabwe.
4/2008	High prevalence of the CYP2B6 516G-->T(*6) variant and effect on the population pharmacokinetics of efavirenz in HIV/AIDS outpatients in Zimbabwe.

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Collen Masimirembwa Research Topics

Disease

5	Breast Neoplasms (Breast Cancer) 10/2023 - 01/2023
5	Acquired Immunodeficiency Syndrome (AIDS) 03/2015 - 04/2008
4	Drug-Related Side Effects and Adverse Reactions 01/2021 - 09/2013
4	Malaria 01/2016 - 01/2012
2	Body Weight (Weight, Body) 11/2023 - 03/2015
2	HIV Infections (HIV Infection) 02/2023 - 10/2016
2	Neoplasms (Cancer) 01/2023 - 09/2014
2	Sickle Cell Anemia (Hemoglobin S Disease) 01/2023 - 03/2015
2	COVID-19 12/2021 - 06/2020
2	Glucosephosphate Dehydrogenase Deficiency 12/2021 - 06/2020
2	Infections 10/2019 - 01/2016
1	Headache (Headaches) 10/2023
1	Cardiotoxicity 01/2023
1	Schistosomiasis (Bilharziasis) 01/2020
1	Chronic Disease (Chronic Diseases) 10/2016
1	Hypercholesterolemia 01/2016
1	Lipodystrophy 09/2013
1	Hypersensitivity (Allergy) 09/2013
1	Peripheral Nervous System Diseases (PNS Diseases) 09/2013
1	Central Nervous System Diseases (CNS Diseases) 09/2013
1	Falciparum Malaria (Plasmodium falciparum Malaria) 01/2012

Drug/Important Bio-Agent (IBA)

6	efavirenz (Sustiva)FDA Link 10/2019 - 04/2008
4	Tamoxifen FDA LinkGeneric 10/2023 - 01/2023
4	Cytochrome P-450 CYP2B6 (CYP2B6)IBA 01/2021 - 04/2008
3	Hormones (Hormone)IBA 02/2023 - 01/2023
3	EnzymesIBA 01/2023 - 09/2013
2	Cytochrome P-450 CYP2D6 (CYP2D6)IBA 10/2023 - 10/2023
2	Biomarkers (Surrogate Marker)IBA 01/2023 - 09/2013
2	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 12/2021 - 06/2020
2	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA 12/2021 - 06/2020
2	Chloroquine (Aralen)FDA LinkGeneric 12/2021 - 06/2020
1	Dapsone FDA Link 11/2023
1	Desipramine (Pertofrane)FDA LinkGeneric 10/2023
1	4-hydroxy-N-desmethyltamoxifenIBA 10/2023
1	Dacarbazine (DIC)FDA LinkGeneric 01/2023
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2023
1	Praziquantel (Biltricide)FDA Link 01/2020
1	Reverse Transcriptase InhibitorsIBA 10/2019
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2016
1	NiprisanIBA 03/2015
1	ProdrugsIBA 09/2014
1	imidazolium- bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III) (NAMI-A)IBA 09/2014
1	Plant ExtractsIBA 01/2014
1	Isoniazid (Ftivazide)FDA LinkGeneric 09/2013
1	Stavudine (Zerit)FDA LinkGeneric 09/2013
1	Nevirapine (Viramune)FDA Link 09/2013
1	NIPRD-AM1IBA 01/2013
1	Artemether FDA Link 01/2012
1	artemisinin (artemisinine)IBA 01/2012

Therapy/Procedure

2	Therapeutics 10/2023 - 01/2012
2	Drug Therapy (Chemotherapy) 01/2016 - 10/2014
1	Pain Management 01/2023
1	Art Therapy 10/2016